People in the U.S., even if they aren't particularly religious, will often say, "God bless you" or, "bless you" after someone sneezes. Sometimes, however, they will substitute "gesundheit," which gets them out of the blessing business, and is also fun to say.
Gesundheit is a German word that literally means "health." The idea is that a sneeze typically precedes illness.
It entered the English language in the early part of the 20th century, brought to the United States by German-speaking immigrants, even if many Americans today don't realize they're speaking German when they use the word.